Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene

Understanding epistasis is central to biology. For instance, epistatic interactions determine the topography of the fitness landscape and affect the dynamics and determinism of adaptation. However, few empirical data are available, and comparing results is complicated by confounding variation in the...

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Main Authors: Schenk, Martijn F., Szendro, Ivan G., Salverda, Merijn L.M., Krug, Joachim, de Visser, J. Arjan G.M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708503/
https://ncbi.nlm.nih.gov/pubmed/23676768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst096
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