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Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics

Pleiotropy is a key feature of the genotype–phenotype map, and its form and extent have many evolutionary implications, including for the dynamics of adaptation and the evolution of specialization. Similarly, pleiotropic effects of antibiotic resistance mutations may affect the evolution of antibiot...

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Detalhes bibliográficos
Publicado no:Evol Appl
Main Authors: Schenk, Martijn F, Witte, Sariette, Salverda, Merijn L M, Koopmanschap, Bertha, Krug, Joachim, de Visser, J Arjan G M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380919/
https://ncbi.nlm.nih.gov/pubmed/25861383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/eva.12200
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