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Pervasive pairwise intragenic epistasis among sequential mutations in TEM-1 β-lactamase
Interactions between mutations play a central role in shaping the fitness landscape, but a clear picture of intragenic epistasis has yet to emerge. To further reveal the prevalence and patterns of intragenic epistasis, we present a survey of epistatic interactions between sequential mutations in TEM...
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| Pubblicato in: | J Mol Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6502654/ https://ncbi.nlm.nih.gov/pubmed/30922874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.03.020 |
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