Initial Mutations Direct Alternative Pathways of Protein Evolution

Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e. non-additive interaction between mutations that affect fitness) is a mechanism that can contribute to both scenarios. Epistasis can co...

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Detalhes bibliográficos
Main Authors: Salverda, Merijn L. M., Dellus, Eynat, Gorter, Florien A., Debets, Alfons J. M., van der Oost, John, Hoekstra, Rolf F., Tawfik, Dan S., de Visser, J. Arjan G. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048372/
https://ncbi.nlm.nih.gov/pubmed/21408208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001321
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