Initial Mutations Direct Alternative Pathways of Protein Evolution

Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e. non-additive interaction between mutations that affect fitness) is a mechanism that can contribute to both scenarios. Epistasis can co...

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Bibliografiske detaljer
Main Authors: Salverda, Merijn L. M., Dellus, Eynat, Gorter, Florien A., Debets, Alfons J. M., van der Oost, John, Hoekstra, Rolf F., Tawfik, Dan S., de Visser, J. Arjan G. M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048372/
https://ncbi.nlm.nih.gov/pubmed/21408208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001321
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