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Negative epistasis and evolvability in TEM-1 β-lactamase – The thin line between an enzyme’s conformational freedom and disorder
Epistasis is a key factor in evolution, since it determines which combinations of mutations provide adaptive solutions and which mutational pathways towards these solutions are accessible by natural selection. There is growing evidence for the pervasiveness of sign epistasis – a complete reversion o...
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| Publicat a: | J Mol Biol |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718737/ https://ncbi.nlm.nih.gov/pubmed/26004540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.05.011 |
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