Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases

Amyloid-β (Aβ) and hyperphosphorylated tau (p-tau) aggregates form the two discrete pathologies of Alzheimer disease (AD), and oligomeric assemblies of each protein are localized to synapses. To determine the sequence by which pathology appears in synapses, Aβ and p-tau were quantified across AD dis...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Bilousova, Tina, Miller, Carol A., Poon, Wayne W., Vinters, Harry V., Corrada, Maria, Kawas, Claudia, Hayden, Eric Y., Teplow, David B., Glabe, Charles, Albay, Ricardo, Cole, Gregory M., Teng, Edmond, Gylys, Karen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715217/
https://ncbi.nlm.nih.gov/pubmed/26718979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.09.018
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