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Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases

Amyloid-β (Aβ) and hyperphosphorylated tau (p-tau) aggregates form the two discrete pathologies of Alzheimer disease (AD), and oligomeric assemblies of each protein are localized to synapses. To determine the sequence by which pathology appears in synapses, Aβ and p-tau were quantified across AD dis...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Bilousova, Tina, Miller, Carol A., Poon, Wayne W., Vinters, Harry V., Corrada, Maria, Kawas, Claudia, Hayden, Eric Y., Teplow, David B., Glabe, Charles, Albay, Ricardo, Cole, Gregory M., Teng, Edmond, Gylys, Karen H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715217/
https://ncbi.nlm.nih.gov/pubmed/26718979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.09.018
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