Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases

Amyloid-β (Aβ) and hyperphosphorylated tau (p-tau) aggregates form the two discrete pathologies of Alzheimer disease (AD), and oligomeric assemblies of each protein are localized to synapses. To determine the sequence by which pathology appears in synapses, Aβ and p-tau were quantified across AD dis...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Bilousova, Tina, Miller, Carol A., Poon, Wayne W., Vinters, Harry V., Corrada, Maria, Kawas, Claudia, Hayden, Eric Y., Teplow, David B., Glabe, Charles, Albay, Ricardo, Cole, Gregory M., Teng, Edmond, Gylys, Karen H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2016
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715217/
https://ncbi.nlm.nih.gov/pubmed/26718979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.09.018
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