Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4

Apolipoprotein E (apoE) colocalizes with amyloid-β (Aβ) in Alzheimer disease (AD) plaques and in synapses, and evidence suggests that direct interactions between apoE and Aβ are important for apoE's effects in AD. The present work examines the hypothesis that apoE receptors mediate uptake of ap...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Bilousova, Tina, Melnik, Mikhail, Miyoshi, Emily, Gonzalez, Bianca L., Poon, Wayne W., Vinters, Harry V., Miller, Carol A., Corrada, Maria M., Kawas, Claudia, Hatami, Asa, Albay, Ricardo, Glabe, Charles, Gylys, Karen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680253/
https://ncbi.nlm.nih.gov/pubmed/31108099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.04.010
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