Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4

Apolipoprotein E (apoE) colocalizes with amyloid-β (Aβ) in Alzheimer disease (AD) plaques and in synapses, and evidence suggests that direct interactions between apoE and Aβ are important for apoE's effects in AD. The present work examines the hypothesis that apoE receptors mediate uptake of ap...

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Détails bibliographiques
Publié dans:Am J Pathol
Auteurs principaux: Bilousova, Tina, Melnik, Mikhail, Miyoshi, Emily, Gonzalez, Bianca L., Poon, Wayne W., Vinters, Harry V., Miller, Carol A., Corrada, Maria M., Kawas, Claudia, Hatami, Asa, Albay, Ricardo, Glabe, Charles, Gylys, Karen H.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680253/
https://ncbi.nlm.nih.gov/pubmed/31108099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.04.010
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