Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4

Apolipoprotein E (apoE) colocalizes with amyloid-β (Aβ) in Alzheimer disease (AD) plaques and in synapses, and evidence suggests that direct interactions between apoE and Aβ are important for apoE's effects in AD. The present work examines the hypothesis that apoE receptors mediate uptake of ap...

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Vydáno v:Am J Pathol
Hlavní autoři: Bilousova, Tina, Melnik, Mikhail, Miyoshi, Emily, Gonzalez, Bianca L., Poon, Wayne W., Vinters, Harry V., Miller, Carol A., Corrada, Maria M., Kawas, Claudia, Hatami, Asa, Albay, Ricardo, Glabe, Charles, Gylys, Karen H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680253/
https://ncbi.nlm.nih.gov/pubmed/31108099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.04.010
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