Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased with APOE4 and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

Human apolipoprotein E (apoE) isoforms may differentially modulate amyloid-β (Aβ) levels. Evidence suggests physical interactions between apoE and Aβ are partially responsible for these functional effects. However, the apoE/Aβ complex is not a single static structure; rather, it is defined by detect...

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Bibliografische gegevens
Hoofdauteurs: Tai, Leon M., Bilousova, Tina, Jungbauer, Lisa, Roeske, Stephen K., Youmans, Katherine L., Yu, Chunjiang, Poon, Wayne W., Cornwell, Lindsey B., Miller, Carol A., Vinters, Harry V., Van Eldik, Linda J., Fardo, David W., Estus, Steve, Bu, Guojun, Gylys, Karen Hoppens, LaDu, Mary Jo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581407/
https://ncbi.nlm.nih.gov/pubmed/23293020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.442103
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