Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased with APOE4 and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

Human apolipoprotein E (apoE) isoforms may differentially modulate amyloid-β (Aβ) levels. Evidence suggests physical interactions between apoE and Aβ are partially responsible for these functional effects. However, the apoE/Aβ complex is not a single static structure; rather, it is defined by detect...

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Detalhes bibliográficos
Main Authors: Tai, Leon M., Bilousova, Tina, Jungbauer, Lisa, Roeske, Stephen K., Youmans, Katherine L., Yu, Chunjiang, Poon, Wayne W., Cornwell, Lindsey B., Miller, Carol A., Vinters, Harry V., Van Eldik, Linda J., Fardo, David W., Estus, Steve, Bu, Guojun, Gylys, Karen Hoppens, LaDu, Mary Jo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581407/
https://ncbi.nlm.nih.gov/pubmed/23293020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.442103
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