Introducing Human APOE into Aβ Transgenic Mouse Models

Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE(−/−) mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-i...

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Bibliographic Details
Main Authors: Tai, Leon M., Youmans, Katherine L., Jungbauer, Lisa, Yu, Chunjiang, LaDu, Mary Jo
Format: Artigo
Language:Inglês
Published: SAGE-Hindawi Access to Research 2011
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199079/
https://ncbi.nlm.nih.gov/pubmed/22028984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/810981
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