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Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition
BACKGROUND: Having the apolipoprotein E4 (APOE-ϵ4) allele is the strongest genetic risk factor for the development of Alzheimer’s disease (AD). Accumulation of amyloid beta (Aβ) in the brain is influenced by APOE genotype. Transgenic mice co-expressing five familial AD mutations (5xFAD) in the prese...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4077554/ https://ncbi.nlm.nih.gov/pubmed/24948358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-111 |
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