Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for Alzheimer’s disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a soluble oligomeric form (oAβ), is considered a proximal cause of neurodegeneration in AD. Emerging data indicate that levels of...

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Detalhes bibliográficos
Main Authors: Tai, Leon M, Mehra, Shipra, Shete, Varsha, Estus, Steve, Rebeck, G William, Bu, Guojun, LaDu, Mary Jo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897976/
https://ncbi.nlm.nih.gov/pubmed/24386905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-2
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