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Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for Alzheimer’s disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a soluble oligomeric form (oAβ), is considered a proximal cause of neurodegeneration in AD. Emerging data indicate that levels of...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3897976/ https://ncbi.nlm.nih.gov/pubmed/24386905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-2 |
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