Amyloid-β42 Alters Apolipoprotein E Solubility in Brains of Mice with Five Familial AD Mutations

Amyloid plaques composed of the 42 amino acid form of amyloid-beta peptide (Aβ42) are a pathological hallmark of Alzheimer’s disease (AD), but soluble and intraneuronal Aβ42 are the more proximal causes of synaptic dysfunction and neurotoxicity. Apolipoprotein E (apoE) modulates this disease process...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Youmans, Katherine Lynn, Leung, Steffi, Zhang, Juan, Maus, Erika, Baysac, Kathleen, Bu, Guojun, Vassar, Robert, Yu, Chunjiang, LaDu, Mary Jo
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049315/
https://ncbi.nlm.nih.gov/pubmed/21219931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneumeth.2010.12.025
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki