APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ accumulation. However, it remains unclear how the APOE genotype affects plaque morphology, intraneuronal Aβ, soluble Aβ4...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Youmans, Katherine L., Tai, Leon M., Nwabuisi-Heath, Evelyn, Jungbauer, Lisa, Kanekiyo, Takahisa, Gan, Ming, Kim, Jungsu, Eimer, William A., Estus, Steve, Rebeck, G. William, Weeber, Edwin J., Bu, Guojun, Yu, Chunjiang, LaDu, Mary Jo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Neurobiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516726/
https://ncbi.nlm.nih.gov/pubmed/23060451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407957
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg