APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ accumulation. However, it remains unclear how the APOE genotype affects plaque morphology, intraneuronal Aβ, soluble Aβ4...

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Autors principals: Youmans, Katherine L., Tai, Leon M., Nwabuisi-Heath, Evelyn, Jungbauer, Lisa, Kanekiyo, Takahisa, Gan, Ming, Kim, Jungsu, Eimer, William A., Estus, Steve, Rebeck, G. William, Weeber, Edwin J., Bu, Guojun, Yu, Chunjiang, LaDu, Mary Jo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516726/
https://ncbi.nlm.nih.gov/pubmed/23060451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407957
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