APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ accumulation. However, it remains unclear how the APOE genotype affects plaque morphology, intraneuronal Aβ, soluble Aβ4...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Youmans, Katherine L., Tai, Leon M., Nwabuisi-Heath, Evelyn, Jungbauer, Lisa, Kanekiyo, Takahisa, Gan, Ming, Kim, Jungsu, Eimer, William A., Estus, Steve, Rebeck, G. William, Weeber, Edwin J., Bu, Guojun, Yu, Chunjiang, LaDu, Mary Jo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Neurobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516726/
https://ncbi.nlm.nih.gov/pubmed/23060451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407957
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