Deletion of Adenosine A(2A) Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

BACKGROUND: Adenosine A(2A) receptors (A(2A)R) modulate dopamine and glutamate signaling and thereby may influence some of the psychomotor and cognitive processes associated with schizophrenia. Because astroglial A(2A)R regulate the availability of glutamate, we hypothesized that they might play an...

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Publicado en:Biol Psychiatry
Autores principales: Matos, Marco, Shen, Hai-Ying, Augusto, Elisabete, Wang, Yumei, Wei, Catherine J., Wang, Yu Tian, Agostinho, Paula, Boison, Detlev, Cunha, Rodrigo A., Chen, Jiang-Fan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714966/
https://ncbi.nlm.nih.gov/pubmed/25869810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.02.026
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