Deletion of Adenosine A(2A) Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

BACKGROUND: Adenosine A(2A) receptors (A(2A)R) modulate dopamine and glutamate signaling and thereby may influence some of the psychomotor and cognitive processes associated with schizophrenia. Because astroglial A(2A)R regulate the availability of glutamate, we hypothesized that they might play an...

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Библиографические подробности
Опубликовано в: :Biol Psychiatry
Главные авторы: Matos, Marco, Shen, Hai-Ying, Augusto, Elisabete, Wang, Yumei, Wei, Catherine J., Wang, Yu Tian, Agostinho, Paula, Boison, Detlev, Cunha, Rodrigo A., Chen, Jiang-Fan
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714966/
https://ncbi.nlm.nih.gov/pubmed/25869810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.02.026
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