Deletion of Adenosine A(2A) Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

BACKGROUND: Adenosine A(2A) receptors (A(2A)R) modulate dopamine and glutamate signaling and thereby may influence some of the psychomotor and cognitive processes associated with schizophrenia. Because astroglial A(2A)R regulate the availability of glutamate, we hypothesized that they might play an...

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Publicado no:Biol Psychiatry
Main Authors: Matos, Marco, Shen, Hai-Ying, Augusto, Elisabete, Wang, Yumei, Wei, Catherine J., Wang, Yu Tian, Agostinho, Paula, Boison, Detlev, Cunha, Rodrigo A., Chen, Jiang-Fan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714966/
https://ncbi.nlm.nih.gov/pubmed/25869810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.02.026
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