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The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with high mortality. Treatments, which can result in significant morbidity, have not substantially changed in three decades. The second messenger cyclic GMP (cGMP), which targets protein kinase G (PKG), is generated by guanylate...

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Détails bibliographiques
Publié dans:Cancer Lett
Auteurs principaux: Tuttle, Traci R., Mierzwa, Michelle L., Wells, Susanne I., Fox, Sejal R., Ben-Jonathan, Nira
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711273/
https://ncbi.nlm.nih.gov/pubmed/26551887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.10.024
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