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Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells

Head and neck squamous cell carcinoma (HNSCC) is an aggressive and often fatal disease. Cisplatin is the most common chemotherapeutic drug in the treatment of HNSCC, but intrinsic and acquired resistance are frequent, and severe side effects occur at high doses. The second messenger cyclic GMP (cGMP...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Tuttle, Traci R., Takiar, Vinita, Kumar, Bhavna, Kumar, Pawan, Ben-Jonathan, Nira
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313285/
https://ncbi.nlm.nih.gov/pubmed/28025101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2016.12.020
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