Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

The Wnt signaling pathway plays a key role in regulation of organ development and tissue homeostasis. Dysregulated Wnt activity is one of the major underlying mechanisms responsible for many diseases including cancer. We previously reported the FDA-approved anthelmintic drug Niclosamide inhibits Wnt...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem
Main Authors: Mook, Robert A., Wang, Jiangbo, Ren, Xiu-Rong, Chen, Minyong, Spasojevic, Ivan, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710091/
https://ncbi.nlm.nih.gov/pubmed/26272032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.001
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares