The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling

Wnt proteins bind to seven-transmembrane Frizzled receptors to mediate the important developmental, morphogenetic, and tissue-regenerative effects of Wnt signaling. Dysregulated Wnt signaling is associated with many cancers. Currently there exist no drug candidates, or even tool compounds that modul...

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Bibliografiske detaljer
Main Authors: Chen, Minyong, Wang, Jiangbo, Lu, Jiuyi, Bond, Michael C., Ren, Xiu-Rong, Lyerly, H. Kim, Barak, Larry S., Chen, Wei
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801776/
https://ncbi.nlm.nih.gov/pubmed/19772353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9009677
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