Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

The Wnt signaling pathway plays a key role in regulation of organ development and tissue homeostasis. Dysregulated Wnt activity is one of the major underlying mechanisms responsible for many diseases including cancer. We previously reported the FDA-approved anthelmintic drug Niclosamide inhibits Wnt...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Bioorg Med Chem
Hlavní autoři: Mook, Robert A., Wang, Jiangbo, Ren, Xiu-Rong, Chen, Minyong, Spasojevic, Ivan, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710091/
https://ncbi.nlm.nih.gov/pubmed/26272032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.001
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky