Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

The Wnt signaling pathway plays a key role in regulation of organ development and tissue homeostasis. Dysregulated Wnt activity is one of the major underlying mechanisms responsible for many diseases including cancer. We previously reported the FDA-approved anthelmintic drug Niclosamide inhibits Wnt...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem
Asıl Yazarlar: Mook, Robert A., Wang, Jiangbo, Ren, Xiu-Rong, Chen, Minyong, Spasojevic, Ivan, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710091/
https://ncbi.nlm.nih.gov/pubmed/26272032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.001
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller