Nalaganje...

Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

The Wnt signaling pathway plays a key role in regulation of organ development and tissue homeostasis. Dysregulated Wnt activity is one of the major underlying mechanisms responsible for many diseases including cancer. We previously reported the FDA-approved anthelmintic drug Niclosamide inhibits Wnt...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Mook, Robert A., Wang, Jiangbo, Ren, Xiu-Rong, Chen, Minyong, Spasojevic, Ivan, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710091/
https://ncbi.nlm.nih.gov/pubmed/26272032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.001
Oznake: Označite
Brez oznak, prvi označite!