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Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth
The Wnt signaling pathway is critical for normal tissue development and is an underlying mechanism of disease when dysregulated. Previously, we reported that the drug Niclosamide inhibits Wnt/β-catenin signaling by decreasing the cytosolic levels of Dishevelled and β-catenin, and inhibits the growth...
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| Publicado no: | Bioorg Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6688896/ https://ncbi.nlm.nih.gov/pubmed/30274939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.09.016 |
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