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Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype

Dysregulation of the Wnt signaling pathway is an underlying mechanism in multiple diseases, particularly in cancer. Until recently, identifying agents that target this pathway has been difficult and as a result, no approved drugs exist that specifically target this pathway. We reported previously th...

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Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Main Authors: Mook Jr, Robert A., Wang, Jiangbo, Ren, Xiu-Rong, Piao, Hailan, Lyerly, H. Kim, Chen, Wei
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688898/
https://ncbi.nlm.nih.gov/pubmed/30551901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.11.022
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