VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction

Vascular endothelial growth factor (VEGF) induces phosphorylation of VEGF receptor-2 (VEGFR-2) and activates the downstream signaling pathway resulting in endothelial cell migration, proliferation, and survival. Cigarette smoking is associated with abnormal vascular and endothelial function, leading...

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Pubblicato in:FASEB J
Autori principali: Edirisinghe, Indika, Yang, Se-Ran, Yao, Hongwei, Rajendrasozhan, Saravanan, Caito, Samuel, Adenuga, David, Wong, Chelsea, Rahman, Arshad, Phipps, Richard P., Jin, Zheng-Gen, Rahman, Irfan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4708085/
https://ncbi.nlm.nih.gov/pubmed/18263699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-099481
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