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Cigarette Smoke–induced Oxidative/Nitrosative Stress Impairs VEGF- and Fluid Shear Stress–Mediated Signaling in Endothelial Cells

VEGF receptor 2 (VEGFR2), a tyrosine kinase receptor, is activated by VEGF and fluid shear stress (FSS), and its downstream signaling is important in the regulation of endothelial functions, such as cell migration, endothelium-dependent relaxation, and angiogenesis. Cigarette smoke (CS) is known to...

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Detalhes bibliográficos
Main Authors: Edirisinghe, Indika, Arunachalam, Gnanapragasam, Wong, Chelsea, Yao, Hongwei, Rahman, Arshad, Phipps, Richard P., Jin, Zheng-Gen, Rahman, Irfan
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864667/
https://ncbi.nlm.nih.gov/pubmed/19929443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2009.2874
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