Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice

The cyclin-dependent kinase inhibitor p21(CIP1/WAF1/SDI1) (p21) is an important inhibitory checkpoint regulator of cell cycle progression in response to oxidative and genotoxic stresses. It is known that p21 potentiates inflammatory response and inhibits apoptosis and proliferation, leading to cellu...

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Detalhes bibliográficos
Main Authors: Yao, Hongwei, Yang, Se-Ran, Edirisinghe, Indika, Rajendrasozhan, Saravanan, Caito, Samuel, Adenuga, David, O'Reilly, Michael A., Rahman, Irfan
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440259/
https://ncbi.nlm.nih.gov/pubmed/18239191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0342OC
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