Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice

The cyclin-dependent kinase inhibitor p21(CIP1/WAF1/SDI1) (p21) is an important inhibitory checkpoint regulator of cell cycle progression in response to oxidative and genotoxic stresses. It is known that p21 potentiates inflammatory response and inhibits apoptosis and proliferation, leading to cellu...

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Détails bibliographiques
Auteurs principaux: Yao, Hongwei, Yang, Se-Ran, Edirisinghe, Indika, Rajendrasozhan, Saravanan, Caito, Samuel, Adenuga, David, O'Reilly, Michael A., Rahman, Irfan
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2008
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440259/
https://ncbi.nlm.nih.gov/pubmed/18239191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0342OC
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