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Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke
RATIONALE: IκB kinase (IKK) activates NF-κB which plays a pivotal role in pro-inflammatory response in the lung. NF-κB has been shown to be activated in alveolar macrophages and peripheral lungs of smokers and patients with COPD. We investigated the anti-inflammatory effect of a highly selective and...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850968/ https://ncbi.nlm.nih.gov/pubmed/20080200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pupt.2010.01.002 |
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