Protein Kinase Cζ Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications

Atypical protein kinase C (PKC) ζ is an important regulator of inflammation through activation of the nuclear factor-κB (NF-κB) pathway. Chromatin remodeling on pro-inflammatory genes plays a pivotal role in cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced abnormal lung inflammation. Howev...

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Hlavní autoři: Yao, Hongwei, Hwang, Jae-woong, Moscat, Jorge, Diaz-Meco, Maria T., Leitges, Michael, Kishore, Nandini, Li, Xiong, Rahman, Irfan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820769/
https://ncbi.nlm.nih.gov/pubmed/20007975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041418
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