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Histone Deacetylase 2 Is Phosphorylated, Ubiquitinated, and Degraded by Cigarette Smoke

Cigarette smoke (CS)–induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who smoke cigarettes. However, the molecular mech...

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Bibliografiske detaljer
Main Authors: Adenuga, David, Yao, Hongwei, March, Thomas H., Seagrave, JeanClare, Rahman, Irfan
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660563/
https://ncbi.nlm.nih.gov/pubmed/18927347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0255OC
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