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Targeted disruption of NF-κB1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling
NF-κB-mediated proinflammatory response to cigarette smoke (CS) plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The heterodimer of RelA/p65-p50 (subunits of NF-κB) is involved in transactivation of NF-κB-dependent genes, but interestingly p50 has no transact...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822556/ https://ncbi.nlm.nih.gov/pubmed/19965984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00265.2009 |
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