β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer’s disease (AD). However, the exact relationship between BACE1 and PHF (Paired Helical Filaments) formation is not clear. In this study,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Cell Neurosci
Päätekijät: Piedrahita, Diego, Castro-Alvarez, John Fredy, Boudreau, Ryan L., Villegas-Lanau, Andres, Kosik, Kenneth S., Gallego-Gomez, Juan Carlos, Cardona-Gómez, Gloria Patricia
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2016
Aiheet:
Neuroscience
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705306/
https://ncbi.nlm.nih.gov/pubmed/26778963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00498
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