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p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice

Alzheimer’s disease (AD) is a proteinopathy characterized by the accumulation of β-amyloid (Aβ) and tau. To date, clinical trials indicate that Aβ immunotherapy does not improve cognition. Consequently, it is critical to modulate other aspects of AD pathology. As such, tau represents an excellent ta...

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Publicat a:Neurosci Lett
Autors principals: Walls, Ken C., Ager, Rahasson R., Vasilevko, Vitaly, Cheng, Dave, Medeiros, Rodrigo, LaFerla, Frank M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437620/
https://ncbi.nlm.nih.gov/pubmed/24887583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2014.05.047
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