p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice

Alzheimer’s disease (AD) is a proteinopathy characterized by the accumulation of β-amyloid (Aβ) and tau. To date, clinical trials indicate that Aβ immunotherapy does not improve cognition. Consequently, it is critical to modulate other aspects of AD pathology. As such, tau represents an excellent ta...

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Veröffentlicht in:Neurosci Lett
Hauptverfasser: Walls, Ken C., Ager, Rahasson R., Vasilevko, Vitaly, Cheng, Dave, Medeiros, Rodrigo, LaFerla, Frank M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437620/
https://ncbi.nlm.nih.gov/pubmed/24887583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2014.05.047
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