Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice

Accumulation of amyloid-β plaques and tau contribute to the pathogenesis of Alzheimer’s disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-β causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an essential antioxidant ele...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Van der Jeugd, Ann, Parra-Damas, Arnaldo, Baeta-Corral, Raquel, Soto-Faguás, Carlos M., Ahmed, Tariq, LaFerla, Frank M., Giménez-Llort, Lydia, D’Hooge, Rudi, Saura, Carlos A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915484/
https://ncbi.nlm.nih.gov/pubmed/29691439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24741-0
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