β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer’s disease (AD). However, the exact relationship between BACE1 and PHF (Paired Helical Filaments) formation is not clear. In this study,...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Cell Neurosci
Egile Nagusiak: Piedrahita, Diego, Castro-Alvarez, John Fredy, Boudreau, Ryan L., Villegas-Lanau, Andres, Kosik, Kenneth S., Gallego-Gomez, Juan Carlos, Cardona-Gómez, Gloria Patricia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2016
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705306/
https://ncbi.nlm.nih.gov/pubmed/26778963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00498
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