PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

BACKGROUND: Initially identified as a molecule that regulates the final step of glycolysis, the M2 isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the metabolic reprogramming of cancer cells as well as participating in cell cycle progression and gene transcription....

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Publicado en:Mol Cancer
Autores principales: Azoitei, Ninel, Becher, Alexander, Steinestel, Konrad, Rouhi, Arefeh, Diepold, Kristina, Genze, Felicitas, Simmet, Thomas, Seufferlein, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704385/
https://ncbi.nlm.nih.gov/pubmed/26739387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0490-2
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