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PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
BACKGROUND: Initially identified as a molecule that regulates the final step of glycolysis, the M2 isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the metabolic reprogramming of cancer cells as well as participating in cell cycle progression and gene transcription....
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| Publicado no: | Mol Cancer |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704385/ https://ncbi.nlm.nih.gov/pubmed/26739387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0490-2 |
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