Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2

The repurposing of existing drugs has emerged as an attractive additional strategy to the development of novel compounds in the fight against cancerous diseases. Inhibition of phosphodiesterase 5 (PDE5) has been claimed as a potential approach to target various cancer subtypes in recent years. Howev...

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Dettagli Bibliografici
Pubblicato in:Carcinogenesis
Autori principali: Chen, Lu, Liu, Yang, Becher, Alexander, Diepold, Kristina, Schmid, Evi, Fehn, Adrian, Brunner, Cornelia, Rouhi, Arefeh, Chiosis, Gabriela, Cronauer, Marcus, Seufferlein, Thomas, Azoitei, Ninel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Carcinogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566345/
https://ncbi.nlm.nih.gov/pubmed/31917403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgaa001
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