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G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins
Activation of brain melanocortin 4 receptors (MC4Rs) leads to reduced food intake, increased energy expenditure, increased insulin sensitivity, and reduced linear growth. MC4R effects on energy expenditure and glucose metabolism are primarily mediated by the G protein G(s)α in brain regions outside...
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| Pubblicato in: | J Clin Invest |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4701544/ https://ncbi.nlm.nih.gov/pubmed/26595811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76348 |
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