G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins

Activation of brain melanocortin 4 receptors (MC4Rs) leads to reduced food intake, increased energy expenditure, increased insulin sensitivity, and reduced linear growth. MC4R effects on energy expenditure and glucose metabolism are primarily mediated by the G protein G(s)α in brain regions outside...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Li, Yong-Qi, Shrestha, Yogendra, Pandey, Mritunjay, Chen, Min, Kablan, Ahmed, Gavrilova, Oksana, Offermanns, Stefan, Weinstein, Lee S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701544/
https://ncbi.nlm.nih.gov/pubmed/26595811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76348
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