Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy

Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell subsets results in superior persistence and antitumor immunity compared with ACT of populations containing more-differentiated effector memory and effector T cells. Despite a clear advantage of the less-diffe...

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Опубликовано в: :J Clin Invest
Главные авторы: Klebanoff, Christopher A., Scott, Christopher D., Leonardi, Anthony J., Yamamoto, Tori N., Cruz, Anthony C., Ouyang, Claudia, Ramaswamy, Madhu, Roychoudhuri, Rahul, Ji, Yun, Eil, Robert L., Sukumar, Madhusudhanan, Crompton, Joseph G., Palmer, Douglas C., Borman, Zachary A., Clever, David, Thomas, Stacy K., Patel, Shashankkumar, Yu, Zhiya, Muranski, Pawel, Liu, Hui, Wang, Ena, Marincola, Francesco M., Gros, Alena, Gattinoni, Luca, Rosenberg, Steven A., Siegel, Richard M., Restifo, Nicholas P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701537/
https://ncbi.nlm.nih.gov/pubmed/26657860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81217
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