Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics

Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) can result in complete regression of advanced cancer in some patients, but the efficacy of this potentially curative therapy might be limited by poor persistence of TIL after adoptive-transfer. Pharmacologic inhibition...

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Publicat a:Cancer Res
Autors principals: Crompton, Joseph G., Sukumar, Madhusudhanan, Roychoudhuri, Rahul, Clever, David, Gros, Alena, Eil, Robert, Tran, Eric, Hanada, Ken-ichi, Yu, Zhiya, Palmer, Douglas C., Kerkar, Sid P., Michalek, Ryan D., Upham, Trevor, Leonardi, Anthony, Aquavella, Nicholas, Wang, Ena, Marincola, Francesco M., Gattinoni, Luca, Muranski, Pawel, Sundrud, Mark S., Klebanoff, Christopher A., Rosenberg, Steven A., Fearon, Douglas T., Restifo, Nicholas P.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384335/
https://ncbi.nlm.nih.gov/pubmed/25432172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2277
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