Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy

Long-term survival and anti-tumor immunity of adoptively-transferred CD8(+) T cells is dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on metabolic features are not well established. Here we utilized a lipophilic cationic dye tetramethylrhodamine methyl este...

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Détails bibliographiques
Publié dans:Cell Metab
Auteurs principaux: Sukumar, Madhusudhanan, Liu, Jie, Mehta, Gautam U., Patel, Shashank J., Roychoudhuri, Rahul, Crompton, Joseph G., Klebanoff, Christopher A., Ji, Yun, Li, Peng, Yu, Zhiya, Whitehill, Greg D., Clever, David, Eil, Robert L, Palmer, Douglas, Mitra, Suman, Rao, Mahadev, Keyvanfar, Keyvan, Schrump, David, Wang, Ena, Marincola, Francesco, Gattinoni, Luca, Leonard, Warren J, Muranski, Pawel, Finkel, Toren, Restifo, Nicholas P.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747432/
https://ncbi.nlm.nih.gov/pubmed/26674251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.11.002
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