Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy

Long-term survival and anti-tumor immunity of adoptively-transferred CD8(+) T cells is dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on metabolic features are not well established. Here we utilized a lipophilic cationic dye tetramethylrhodamine methyl este...

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Pubblicato in:Cell Metab
Autori principali: Sukumar, Madhusudhanan, Liu, Jie, Mehta, Gautam U., Patel, Shashank J., Roychoudhuri, Rahul, Crompton, Joseph G., Klebanoff, Christopher A., Ji, Yun, Li, Peng, Yu, Zhiya, Whitehill, Greg D., Clever, David, Eil, Robert L, Palmer, Douglas, Mitra, Suman, Rao, Mahadev, Keyvanfar, Keyvan, Schrump, David, Wang, Ena, Marincola, Francesco, Gattinoni, Luca, Leonard, Warren J, Muranski, Pawel, Finkel, Toren, Restifo, Nicholas P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747432/
https://ncbi.nlm.nih.gov/pubmed/26674251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.11.002
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