Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits CD8(+) T cell memory formation

Blimp-1 is a transcriptional repressor that promotes the differentiation of CD8(+) T cells into short-lived KLRG-1(+) effector cells (SLEC), but how it operates remains poorly defined. Here we show that Blimp-1 binds and represses the Id3 promoter in SLEC. Repression of Id3 by Blimp-1 was dispensabl...

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Autori principali: Ji, Yun, Pos, Zoltan, Rao, Mahadev, Klebanoff, Christopher A., Yu, Zhiya, Sukumar, Madhusudhanan, Reger, Robert N., Palmer, Douglas C., Borman, Zachary A., Muranski, Pawel, Wang, Ena, Schrump, David S., Marincola, Francesco M., Restifo, Nicholas P., Gattinoni, Luca
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226770/
https://ncbi.nlm.nih.gov/pubmed/22057288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2153
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