Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics

Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) can result in complete regression of advanced cancer in some patients, but the efficacy of this potentially curative therapy might be limited by poor persistence of TIL after adoptive-transfer. Pharmacologic inhibition...

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Publicado en:Cancer Res
Main Authors: Crompton, Joseph G., Sukumar, Madhusudhanan, Roychoudhuri, Rahul, Clever, David, Gros, Alena, Eil, Robert, Tran, Eric, Hanada, Ken-ichi, Yu, Zhiya, Palmer, Douglas C., Kerkar, Sid P., Michalek, Ryan D., Upham, Trevor, Leonardi, Anthony, Aquavella, Nicholas, Wang, Ena, Marincola, Francesco M., Gattinoni, Luca, Muranski, Pawel, Sundrud, Mark S., Klebanoff, Christopher A., Rosenberg, Steven A., Fearon, Douglas T., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384335/
https://ncbi.nlm.nih.gov/pubmed/25432172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2277
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