Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy

Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell subsets results in superior persistence and antitumor immunity compared with ACT of populations containing more-differentiated effector memory and effector T cells. Despite a clear advantage of the less-diffe...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Klebanoff, Christopher A., Scott, Christopher D., Leonardi, Anthony J., Yamamoto, Tori N., Cruz, Anthony C., Ouyang, Claudia, Ramaswamy, Madhu, Roychoudhuri, Rahul, Ji, Yun, Eil, Robert L., Sukumar, Madhusudhanan, Crompton, Joseph G., Palmer, Douglas C., Borman, Zachary A., Clever, David, Thomas, Stacy K., Patel, Shashankkumar, Yu, Zhiya, Muranski, Pawel, Liu, Hui, Wang, Ena, Marincola, Francesco M., Gros, Alena, Gattinoni, Luca, Rosenberg, Steven A., Siegel, Richard M., Restifo, Nicholas P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701537/
https://ncbi.nlm.nih.gov/pubmed/26657860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81217
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