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Pore Structure and Synergy in Antimicrobial Peptides of the Magainin Family

Magainin 2 and PGLa are among the best-studied cationic antimicrobial peptides. They bind preferentially to negatively charged membranes and apparently cause their disruption by the formation of transmembrane pores, whose detailed structure is still unclear. Here we report the results of 5–9 μs all-...

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Udgivet i:PLoS Comput Biol
Main Authors: Pino-Angeles, Almudena, Leveritt, John M., Lazaridis, Themis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699650/
https://ncbi.nlm.nih.gov/pubmed/26727376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004570
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