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The Structure of a Melittin-Stabilized Pore

Melittin has been reported to form toroidal pores under certain conditions, but the atomic-resolution structure of these pores is unknown. A 9-μs all-atom molecular-dynamics simulation starting from a closely packed transmembrane melittin tetramer in DMPC shows formation of a toroidal pore after 1 μ...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Leveritt, John M., Pino-Angeles, Almudena, Lazaridis, Themis
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457010/
https://ncbi.nlm.nih.gov/pubmed/25992720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.04.006
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